SYNTHESIS OF 5ARYLIDINE2(3, 4, 5TRIMETHOXYPHENYL)3(4PHENYLTHIAZOL2YL) THIAZOLIDIN4ONE DERIVATIVES AS A NOVEL CLASS OF ANTIMICROBIAL AGENTS
Keywords:
2‐Amino‐4‐arylthiazole, Antimicrobial activity, 5‐arylidine, 4‐Thiazolidinone and 3,4,5 trimehoxybenzaldehyde.Abstract
The present work describes the synthesis and in vitro antimicrobial evaluation of 5‐arylidine derivatives of 2‐(3, 4, 5‐trimethoxyphenyl)‐3‐(4‐
phenylthiazol‐2‐yl) thiazolidin‐4‐one (4). The reaction of 2‐amino‐4‐phenylthiazole, 3,4,5 trimethoxybenzaldehyde and mercaptoacetic acid in
presence of DCC yielded 2‐(3, 4, 5‐trimethoxyphenyl)‐3‐(4‐phenylthiazol‐2‐yl) thiazolidin‐4‐one (4) and further 5‐arylidne derivatives (5a5k)
were synthesized by the subsequent reaction of 4 with different aryl aldehydes. All the synthesized compounds were characterized by standard
spectroscopic techniques, evaluated their antibacterial and antifungal activity by agar well diffusion method. The compounds showed some
interesting antibacterial activity. The substitution of 5‐arylidne groups on new thiazolidinone (4) have resulted enhanced antibacterial activity. The
compounds showed moderate antifungal activity in a scattered manner.
