SYNTHESIS, SPECTRAL AND ANTIBACTERIAL STUDIES OF 18- MEMBERED TETRAAZAMACROCYCLIC COMPLEXES DERIVED FROM CARBOHYDRAZIDE AND DIACETONYL

Abstract

A novel series of the macrocyclic complexes of type [M(C14H24N8O2)X]X2, where M = Fe(III) or Cr(III) and X = Cl-1, NO3-1 or CH3COO-1 has been synthesized by [2+2] condensation of carbohydrazide and acetonylacetone (diacetonyl) in the presence of trivalent metal salt in methanolic medium. The complexes were characterized with the help of various physicochemical techniques such as elemental analyses, conductance measurements, electronic and infrared spectral studies. The low value of molar conductance indicates them to be as 1:2 electrolytes. On the basis of various studies, a five coordinate square pyramidal geometry for these complexes has been proposed. All the synthesized macrocyclic complexes were also tested for their in vitro antibacterial activity against some pathogenic bacterial strains. The MIC values shown by the complexes against these bacterial strains were compared with those of the standard antibiotics Ciprofloxacin. Some of the complexes showed good antibacterial activities